Lucas Weber
Principal Chemist
Tesamorelin
Product information
Product description
Tesamorelin is a synthetic growth hormone-releasing hormone analog that binds the GHRH receptor on anterior pituitary somatotrophs, stimulating pulsatile growth hormone release. Because it acts at the physiological point of control, somatostatin feedback is preserved. Requires reconstitution before use.
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Tesamorelin
- Characteristics
- How does Tesamorelin work?
- Research
- Safety & Handling
- Summary
- References
- Resource
- Peptonova Labs peptides
Characteristics
Molecular Formula | C221H366N72O67S |
CAS Number | 218949-48-5 |
Molar Mass | 5135.9 g/mol |
Amino Acid Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 |
Synonyms | TH9507, Egrifta, Lipodystrophy Drug |
Solubility | Water-soluble |
Organoleptic Profile | White to off-white powder |
Composition | Lyophilized powder - requires reconstitution |
How does Tesamorelin work?
Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that has been the subject of extensive research in the field of endocrinology and metabolism. This peptide's primary mechanism of action involves binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland. This activation stimulates the synthesis and pulsatile release of endogenous growth hormone (GH), which in turn promotes the production of insulin-like growth factor-1 (IGF-1) in the liver and other tissues.
Research
Visceral Adipose Tissue (VAT) Reduction: Clinical studies have shown that tesamorelin can significantly reduce VAT in study subjects with HIV-associated lipodystrophy and in obese study subjects without HIV. This reduction in VAT has been associated with improvements in metabolic health markers.
Insulin Sensitivity: Investigations have indicated that tesamorelin treatment may improve insulin sensitivity in certain populations, including study subjects with HIV-associated lipodystrophy and obese study subjects without HIV.
Cognitive Function: Some studies have explored tesamorelin's potential effects on cognitive function in older adults with mild cognitive impairment (MCI). Preliminary findings suggest possible improvements in executive function, attention, and memory.
Muscle tissue: research has examined tesamorelin in relation to lean mass measures in older study populations and in HIV-associated lipodystrophy trials.
Bone Health: Studies have observed increases in bone mineral density (BMD) in study subjects with HIV-associated lipodystrophy following tesamorelin treatment.
Safety & Handling
This section describes laboratory handling. It is not clinical guidance, and no safety claim for human or veterinary administration is made or implied.
Supplied lyophilized. Reconstituted peptide solutions have materially shorter working stability than the dry powder — prepare working aliquots and avoid repeated freeze-thaw cycles.
Handle as a research chemical of undetermined hazard. Use gloves, eye protection and a laboratory coat.
Storage temperature and, where applicable, reconstitution conditions are stated on the item specification sheet and the lot Certificate of Analysis, which take precedence over general guidance.
Dispose of unused material and consumables in accordance with the institutional chemical waste policy.
For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or dietary supplement.
Summary
Tesamorelin is a potent growth hormone-releasing hormone (GHRH) analog that has been extensively researched for its potential to improve metabolic health, reduce visceral adipose tissue (VAT), and enhance cognitive function in various populations. By stimulating the production and release of endogenous growth hormone (GH) from the anterior pituitary gland, tesamorelin promotes the production of insulin-like growth factor-1 (IGF-1), leading to numerous metabolic and cognitive benefits. Published studies have measured changes in visceral adipose tissue, insulin sensitivity, cognitive endpoints, lean mass and bone markers in the study populations examined. As a research peptide, tesamorelin holds promise for further investigating the complex interplay between growth hormone, metabolism, and cognitive function, potentially leading to the development of novel research approaches for various metabolic and cognitive disorders.
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