Lucas Weber
Principal Chemist
TB-500
Product information
Product description
TB-500 corresponds to the actin-binding region of thymosin beta-4, the principal G-actin sequestering protein in mammalian cells. By binding monomeric actin it influences the polymerisation equilibrium governing cell migration and cytoskeletal remodelling. Requires reconstitution before use.
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TB-500
- TB-500 Characteristics
- What is TB-500 and How does it work?
- Areas of Study
- Safety & Handling
- Summary
- References
- Resource
- Peptonova Labs peptides
TB-500 Characteristics
Molecular Formula | C212H350N56O78S |
CAS Number | 77591-33-4 |
Molar Mass | 4963.4 g/mol |
Amino Acid Sequence | Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
Synonyms | Thymosin Beta-4, Tβ4, TMSB4X, PTMB4, TB500 |
Solubility | Water-soluble |
Organoleptic Profile | White to off-white powder |
Composition | Lyophilized powder - requires reconstitution |
What is TB-500 and How does it work?
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide conserved across species and expressed in various tissues. Research has shown that TB-500 interacts with actin, a protein crucial for cell migration and tissue remodeling. This interaction promotes actin polymerization, which is essential for angiogenesis and cell migration to injury sites.
Studies have demonstrated that TB-500 modulates the expression of genes involved in inflammation, wound healing, and tissue regeneration. For instance, it has been found to upregulate matrix metalloproteinases (MMPs), enzymes key to extracellular matrix remodeling and wound healing.
Areas of Study
Research in mammalian models has revealed:
- Wound healing: TB-500 has been shown to enhance keratinocyte and fibroblast migration, stimulate angiogenesis, and reduce inflammation, contributing to faster healing in various wound types.
- Anti-inflammatory effects: Studies have demonstrated TB-500's ability to reduce pro-inflammatory cytokine production and increase anti-inflammatory cytokine levels in various inflammatory conditions.
- Follicle research: studies using mammalian models have measured follicle size and telogen-to-anagen transition.
- Neuroprotection: Studies have explored TB-500's potential to reduce neuroinflammation, oxidative stress, and apoptosis in models of neurological disorders.
- Cardioprotection: In mammalian models of myocardial infarction, TB-500 has been shown to reduce infarct size, improve cardiac function, and promote angiogenesis.
These TB-500 peptide benefits make it an important subject of ongoing research in tissue repair and cellular recovery.
While these findings are promising, it is important to note that TB-500 is currently a research tool, and its effects in mammals are still being studied.
Safety & Handling
This section describes laboratory handling. It is not clinical guidance, and no safety claim for human or veterinary administration is made or implied.
Supplied lyophilized. Reconstituted peptide solutions have materially shorter working stability than the dry powder — prepare working aliquots and avoid repeated freeze-thaw cycles.
Handle as a research chemical of undetermined hazard. Use gloves, eye protection and a laboratory coat.
Storage temperature and, where applicable, reconstitution conditions are stated on the item specification sheet and the lot Certificate of Analysis, which take precedence over general guidance.
Dispose of unused material and consumables in accordance with the institutional chemical waste policy.
For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or dietary supplement.
Summary
TB-500, a synthetic version of the naturally occurring peptide Thymosin Beta-4, has shown remarkable potential in various research settings. The peptide has been studied in models of wound repair, inflammatory signalling, follicle cycling, neuroprotection and cardiac tissue. TB-500 exerts its effects through multiple mechanisms, including its interaction with actin, modulation of gene expression, and regulation of inflammatory pathways.
As a research tool, TB-500 offers a valuable opportunity to explore the complex mechanisms underlying wound healing, inflammation, and tissue regeneration. These studies inform further laboratory investigation across a range of models, from dermal wound and follicle research to neurodegeneration models.
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Resource
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