PT-141 Research Spray Kit (10mg/7ml)

PT-141 primarily acts as a melanocortin receptor agonist, with highest affinity for the melanocortin 4 receptor (MC4R) and melanocortin 1 receptor (MC1R). Research suggests the following mechanisms:

1. Central Nervous System: PT-141 activates MC4R in specific brain regions, particularly the hypothalamus and brainstem areas involved in sexual response. This activation is thought to influence neural pathways related to sexual desire and arousal.

2. Neurotransmitter Modulation: Studies indicate that PT-141 may increase dopamine release in the medial preoptic area, a region crucial for sexual motivation.

3. Peripheral Effects: PT-141's interaction with MC1R on melanocytes has been studied for potential effects on skin pigmentation.

1. HSDD in Premenopausal Women:

• Multiple Phase III clinical trials have evaluated PT-141's efficacy for HSDD.

• Studies typically measured changes in sexual desire and related distress using validated scales like the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO).

• Research has examined various dosing regimens and administration methods.

2. Other Areas of Investigation:

• Male Sexual Function: Some studies have explored potential effects on erectile function, though this is not an FDA-approved use.

• Dermatology: Limited research has investigated PT-141's influence on melanogenesis and potential applications in pigmentation disorders.

• Cardiovascular Effects: Studies have examined PT-141's impact on blood pressure and heart rate, primarily for safety monitoring.

This section describes laboratory handling. It is not clinical guidance, and no safety claim for human or veterinary administration is made or implied.

• Reconstitute the lyophilized vial with the supplied solution before transferring to the spray bottle. Working stability in the spray bottle is shorter than that of the sealed vial; prepare only what the protocol requires.

• Handle as a research chemical of undetermined hazard. Use gloves, eye protection and a laboratory coat.

• Storage temperature and, where applicable, reconstitution conditions are stated on the item specification sheet and the lot Certificate of Analysis, which take precedence over general guidance.

• Dispose of unused material and consumables in accordance with the institutional chemical waste policy.

For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or dietary supplement.

PT-141 (Bremelanotide) is a synthetic peptide that has been the subject of extensive clinical research, particularly in the field of female sexual health. It is approved use for HSDD in premenopausal women represents a significant development in this research area. Ongoing studies continue to explore its mechanisms of action, potential applications, and long-term safety profile.

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7. Kingsberg SA, Clayton AH, Pfaus JG. The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder. CNS Drugs. 2015.

8. Thomas HN, Thurston RC. A biopsychosocial approach to women's sexual function and dysfunction at midlife: A narrative review. Maturitas. 2016.

9. Simon JA, Kingsberg SA, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Rodenberg C, Clayton AH. Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Obstet Gynecol. 2019.

10. Poels S, Bloemers J, van Rooij K, Koppeschaar H, Olivier B, Tuiten A. Two novel combined drug treatments for women with hypoactive sexual desire disorder. Pharmacol Biochem Behav. 2014.

11. Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res. 2004.

12. Altof SE, Ströberg P. The potential of bremelanotide for the treatment of hypoactive sexual desire disorder. Ther Adv Urol. 2013.

13. Pfaus J, Giuliano F, Gelez H. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007.

14. Pfaus JG. Pathways of sexual desire. J Sex Med. 2009.

15. Safarinejad MR, Shafiei N, Safarinejad S. Evaluation of the efficacy and safety of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study. J Sex Med. 2008.

16. Portman DJ, Edelson J, Jordan R, Clayton A, Krychman ML, Kingsberg SA. Bremelanotide for hypoactive sexual desire disorder: analyses from a phase 2B dose-ranging study. J Women's Health. 2014.