GHK-Cu Research Spray Kit (50mg/7ml)

GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine. The free tripeptide occurs in human plasma and its concentration declines with age; the copper complex, not the peptide alone, is the species associated with reported activity in most experimental systems.

The histidine imidazole and the N-terminal amine form a high-affinity chelation site for copper(II), and the resulting complex is understood as a physiological copper delivery vehicle. Copper is a required cofactor for lysyl oxidase, which cross-links collagen and elastin, and for superoxide dismutase — which links the peptide directly to matrix assembly and to redox handling.

Reported transcriptional effects are broad rather than narrow. Gene expression studies describe changes across matrix remodelling, antioxidant response and inflammatory pathways, which is more consistent with a cofactor delivery mechanism than with a single receptor interaction.

This item is supplied as a research spray kit: the lyophilized vial is reconstituted with the supplied solution and transferred to the spray bottle.

Findings below are drawn from published preclinical and clinical work and are presented for research context only.

• Copper carriage. The complex delivers copper(II) to enzymatic sites; lysyl oxidase and superoxide dismutase are the cofactor dependencies most often invoked to explain downstream effects.

• Matrix protein expression. Reported effects on collagen, elastin, proteoglycan and glycosaminoglycan synthesis in dermal fibroblast systems are among the best-replicated observations for the compound.

• Wound models. The peptide has a long literature in dermal and corneal wound models, where reported outcomes include altered closure rate and matrix organisation.

• Gene expression breadth. Transcriptional profiling reports changes across many pathway families simultaneously, which argues against a single-receptor account.

• Speciation matters. Activity is attributed to the copper complex rather than to free tripeptide. Preparations that lose copper speciation should not be assumed equivalent.

This section describes laboratory handling. It is not clinical guidance, and no safety claim for human or veterinary administration is made or implied.

• Reconstitute the lyophilized vial with the supplied solution before transferring to the spray bottle. Working stability in the spray bottle is shorter than that of the sealed vial; prepare only what the protocol requires.

• Handle as a research chemical of undetermined hazard. Use gloves, eye protection and a laboratory coat.

• Storage temperature and, where applicable, reconstitution conditions are stated on the item specification sheet and the lot Certificate of Analysis, which take precedence over general guidance.

• Dispose of unused material and consumables in accordance with the institutional chemical waste policy.

For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or dietary supplement.

GHK-Cu is a copper-carrying tripeptide complex studied principally for effects on extracellular matrix protein expression and tissue repair. Its mechanism is best understood as physiological copper delivery to cofactor-dependent enzymes rather than receptor agonism.

This item is supplied as a research spray kit comprising a 50 mg vial, reconstitution solution and spray bottle. The copper complex, not the free tripeptide, is the species of interest.

1. Hu J, Zhang C, Wang F. Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model. Eur J Pharmacol. 2026;1023:178880.

2. Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR. Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective. Bioimpacts. 2025;15:30071.

3. Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiol Ther. 2020;2(1):58-61.

4. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7).

5. Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.